Dimitris Vrachnos, MSc
PhD Student | Bioinformatician
Dimitris is a bioinformatician with specialized expertise in multi-omics data analysis within the biotechnology industry. His interdisciplinary foundation was built through a Bsc in Biology and MSc in Biomedical Engineering from the University of Hull, followed by a specialized MSc in Omics Data Analysis from the University of Vic (UVic), Spain. He is currently advancing his research by pursuing an industrial PhD with the CUT, conducted in parallel with his role at Stremble. As a key member of Stremble's bioinformatics and computational biology team, his work involves analyzing and interpreting large-scale data from diverse 'omics' fields—including genomics, transcriptomics, and metagenomics. This expertise is mission-critical for the company's involvement in major multi-country, EU-funded research projects. His role is central to the Horizon 2020 Cardiocare project, a multi-disciplinary study on breast cancer therapy-induced cardiotoxicity. In this project, Stremble leads the omics work package, where Dimitris is responsible for processing and analyzing the gene sequencing, transcriptomics (miRNA), and metagenomics data from the multi-centre clinical study. His industrial PhD links directly to the Horizon Europe Comfortage project, a multi-country initiative focused on personalized prevention for dementia and frailty, where Stremble and CUT collaborate, with Stremble acting as the Scientific Manager overseeing 13 clinical and pilot studies. This position allows him to blend his deep analytical skills with high-level project oversight, translating complex biological data into meaningful insights for pressing health challenges. His expertise also extends to high-impact translational research, highlighted by his contribution to the Myeloma-Risk project. This prestigious European Research Council Proof-of-Concept grant, in partnership with the University of Milan, aims to develop a novel diagnostic tool for high-risk smoldering myeloma. Dimitris's role is key to this, involving the advanced bioinformatic analysis of mutational signatures and supporting the development of the IPR and commercialization strategy to bring the tool to market. His broader portfolio of bioinformatics includes other foundational projects within Cyprus. He has led the analytics for the Cyprus Genome Project, a major initiative establishing a large-scale genetic variant database for the Cypriot population, and headed the multi-omics analysis for the Molecular Colonoscopy (MOCO) project, which developed new risk-assessment tools for colorectal cancer. Looking ahead, Dimitris is focusing his PhD research on innovating at the intersection of computational biology and AI. His primary interests include researching novel models for Digital Twins and developing new AI-based solutions to address classic statistical challenges in multi-omics analysis. He aims to leverage his industrial and research experience to create more robust and interpretable predictive models that translate complex biological data into personalized healthcare.